ACCUTANE Dragon Pharma

DG ACCUTANE is a potent retinoid. The latter refers to a derivative of vitamin A. It has as active substance – Isotretinoin – known as retinoic acid and has the form of a yellowish powder. This substance is capable of neutralizing the rapidly dividing cancer cells. This property was originally used for the treatment of cancer pathologies.

After some time, scientists have found another therapeutic properties of this powdery substance – it is able to reduce sebum production by inhibiting the excessive cell growth of the epithelium of the excretory ducts. This Accutane property allows you now to use it to treat severe acne. The formulations based on this active ingredient can be used both externally and orally. Optimal dosage selects dermatologist after examination of the patient.

Accutane instruction manual recommends that you use it to effectively treat acne scars and other skin diseases. The therapeutic effect of the drug has an effect directly on all the factors that trigger these diseases. First of all, it is reduced the production of sebum, pores are cleaned. Systemic retinoid prevents the growth of pathological microorganisms – Propionibacterium acnes, which causes acne, pimples.

Normalization of pH it is also a merit of the drug. Accutane is actively used in dermatology and cosmetology, alos in bodybuilding during post cycle therapy. Active component allows you to influence not only on the symptoms of the disease, but also to eliminate the reasons that led to the development of the inflammatory process.

Accutane Uses:

Isotretinoin produces its effects through altering progress through the cell cycle, cell differentiation, survival, and apoptosis. These actions reduce sebum production, preventing the blockage of pores, and growth of acne causing bacteria. Isotretinoin and 4-oxo-isotretinoin both significantly reduce the production of sebum. Label Isotretinoin has little to no affinity for retinol binding proteins (RBPs) and retinoic acid nuclear receptors (RARs).Tretinoin and 4-oxo-tretinion bind to the RAR-γ receptor, which is suspected to be part of the action of acne treatment by isotretinoin.

Isotretinoin induces apoptosis in sebocytes, leading to a decrease in sebum production. Isotretinoin also reduces the formation of comedones by reducing hyperkeratinization through an unknown mechanism. Isotretinoin does not directly kill bacteria but it does reduce the size of sebum ducts and makes the microenvironment less hospitable to acne causing bacteria. It may also increase immune mechanisms and alter chemotaxis of monocytes to reduce inflammation.

Average daily dose (0.5 grams) must be divided into several stages. Depending on the severity of the illness – it may be increased. Note that in the night it can be taken no more than 10 grams of Isotretinoin. Drug treatment is usually long-term, 16-24 weeks. The interval between cycles of therapy should be at least two months.

Accutane Side Effects:

If you exceed the dosage, Accutane causes side effects. They appear on the part of the immune system more often. Patients complain of rashes, redness, peeling of the skin on the palms and soles of the feet, itching, nail dystrophy plates. It is also possible the emergence of cheilitis – disease affecting the skin on the lips.

Nervous system, some patients are also suffering due to the treatment with Accutane drug. Reviews suggest that may appear headache, excessive fatigue, impaired visual acuity, developing depression and psychosis. People with asthma history, taking this drug is extremely dangerous. This may lead to bronchoconstriction. Side effects on the organs of vision are manifested by symptoms such as keratitis, blepharitis, optic neuritis, conjunctivitis, eye irritation.

On the part of the digestive tract, it develops pancreatitis, diarrhea, internal bleeding, vomiting, inflammation of the intestinal mucosa, hepatitis. Arthritis pain in the joints and muscles, hyperostosis – these are symptoms of adverse effects of Accutane on the musculoskeletal system.

Many patients successfully used for the treatment with products based on the active substance such as Isotretinoin. Analogs of these drugs should choose a specialist.

In just a few months of therapy, this powerful natural retinoid allows you to get rid of acne, acne rosacea. More severe skin disease are requiring repeated courses of therapy. Only in rare cases, the side effects occur, most often seen by the immune system: allergic rash, dry dermis redness. It is strictly forbidden to take drugs based on Isotretinoin during pregnancy planning, gestation or lactation of a baby.